. Author manuscript; available in PMC: 2014 Aug 18.

Published in final edited form as: J Pharmacol Toxicol Methods. 2013 May 5;68(1):112–122. doi: 10.1016/j.vascn.2013.04.007

Table 2.

Results of a screen for a number of compounds with varying ion-channel blocking profiles. These screens were performed once for each ion channel at AZ. Where 50% block was not achieved, we have performed a least-squares fit of a concentration-effect curve to the original data, with a minimum allowed pIC₅₀ of 0, a minimum allowed Hill coefficient of 0.5, and a maximum of 5.00.

Compound	hERG		NaV1.5		CaV1.2		KCNQ1/minK		Kv4.3/KChIP2.2
	pIC₅₀	Hill	pIC₅₀	Hill	pIC₅₀	Hill	pIC₅₀	Hill	pIC₅₀	Hill
Alfuzosin	4.66	0.92	3.69	0.71	3.75	1.64	3.95	0.50	3.04	0.50
Dofetilide	6.85	1.88	3.46	0.79	3.77	5.00	3.65	0.50	0.00	1.00
Lacosamide	0.00	1.00	3.34	0.72	4.33	0.44	3.62	0.50	0.00	1.00
Nilotinib	4.20	0.53	2.97	0.71	3.67	0.67	3.39	0.50	2.48	0.72
Tolterodine	6.89	1.58	5.24	1.08	0.00	1.00	4.10	0.60	4.93	1.07