Table 4.
Uncertainty in concentration-effect curves for action potential duration under the action of Alfuzosin, when considering ion-channel assay variability in pIC50 values and Hill coefficients, for various numbers of repeats. Each plot displays action potential duration, APD90, as a function of concentration. Black lines represent simulation results for each set of sampled concentration-effect inputs, the red line denotes the result when using the numbers reported by the assay directly, with 95% credibility intervals imposed as described in the text.
|