. Author manuscript; available in PMC: 2015 Aug 15.

Published in final edited form as: Bioorg Med Chem Lett. 2014 Jul 9;24(16):3728–3731. doi: 10.1016/j.bmcl.2014.07.006

Table 1.

Class I HDAC isoform selectivity of 3–6

compound

IC₅₀ (nM)

\frac{{IC}_{50} (HDAC 2)}{{IC}_{50} (HDAC 1)}

\frac{{IC}_{50} (HDAC 3)}{{IC}_{50} (HDAC 1)}

HDAC1

HDAC2

HDAC3

HDAC8

2^a

0.40

0.90

0.70

102

2.3

1.8

0.29

1.70

0.68

NI^b

5.9

2.3

0.21

1.10

0.38

NI^b

5.2

1.8

0.20

1.40

1.10

NI^b

7.0

5.5

150

100

NI^b

3.9

2.6

Data from ref. 5.

No inhibition up to 1 μM.