Table 2.

Class I HDAC isoform selectivity of 7–11

compound	R	IC50 (nM)				$\frac{{\text{IC}}_{50}(\text{HDAC}2)}{{\text{IC}}_{50}(\text{HDAC}1)}$	$\frac{{\text{IC}}_{50}(\text{HDAC}3)}{{\text{IC}}_{50}(\text{HDAC}1)}$
		HDAC1	HDAC2	HDAC3	HDAC8
2a		0.40	0.90	0.70	102	2.3	1.8
7		5.50	21.00	7.80	NIb	3.8	1.4
8		3.30	6.30	6.00	NIb	1.9	1.8
9		2.30	3.10	4.20	NIb	1.4	1.8
10		0.96	1.40	1.80	790	1.5	1.9
11		0.62	1.10	1.10	540	1.8	1.8

^aData from ref. 5.

^bNo inhibition up to 1 μM.