Figure 2.

Areas of significant gray matter differences at ANCOVA (including correction for age and total intracranial volume, less than 1 false-positive cluster expected, P < 0.005) between normal volunteers and nonresponder schizophrenia patients, superimposed onto the average of the normalized GM volumes. Right side of the brain is at the observer's right. GM reduction in nonresponder schizophrenia patients involves mainly the frontal lobes bilaterally. Superior and middle frontal gyri are involved on the left, extending into the pre- and postcentral gyri, while on the right mainly middle frontal gyrus and insula are involved. Additionally, right medial temporal lobe (mainly amygdala) is involved.