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. 2014 Jul 23;2014:261409. doi: 10.1155/2014/261409

Table 4.

Characteristics of included studies.

Study Animal species Injury model Main experimental groups Method/dose of
statin administration		 Anesthetic agent Time of statin administration Time of outcome measurement Quality score
Abrahamson et al., 2009 [24] Male
APPNLh/NLh mice		 CCI (1) TBI + vehicle (n = 5-6)
(2) TBI + simvastatin (n = 5-6)		 Orally,
3 mg/kg/d		 Isoflurane 3 h after injury 10–14 d after injury 5
Chauhan and Gatto, 2011 [16] Male C57BL/6J mice CCI (1) TBI+ saline (n = 8)
(2) TBI + pravastatin (n = 12)
(3) TBI + lovastatin (n = 9)
(4) TBI + simvastatin (n = 8)		 Orally,
2 mg/kg/d
for 8 weeks		 Ketamine immediately after injury 7-8 weeks after injury 3
Indraswari et al., 2012 [25] Male C57BL/6J mice CCI (1) TBI + saline (n = 12)
(2) TBI + rosuvastatin (n = 12)		 Orally,
1 mg/kg/d
for 5 d		 Isoflurane within 1 h after injury 31–34 d after injury 8
Lu et al., 2004 [26] Male
Wistar rats		 CCI (1) TBI + saline (n = 4)
(2) TBI + atorvastatin (n = 4)		 Orally,
1 mg/kg/d
for 7 d		 Chloral hydrate 1 d after injury 1, 4, 8, and 15 d after injury 7
Lu et al., 2007 [13] Male
Wistar rats		 CCI (1) TBI + saline (n = 10)
(2) TBI + atorvastatin (n = 10)
and
(1) TBI + saline (n = 10)
(2) TBI + atorvastatin (n = 10)
(3) TBI + simvastatin (n = 10)		 orally
1 mg/kg/d
for 14 d		 Chloral hydrate 1 d after injury 11–15 and
31–35 d after injury		 7
Wang et al., 2012 [27] Male
Wistar rats		 FPI (1) TBI + control (n = 10)
(2) TBI + atorvastatin (n = 10)		 Orally,
1 mg/kg/d
for 14 d		 Chloral hydrate 1 h after injury 21–25 d after injury 5
Wang et al., 2007 [28] Male C57Bl/6J mice CHI (1) TBI + vehicle (n = ?)
(2) TBI + simvastatin (n = ?)
(3) TBI + atorvastatin (n = ?)		 Subcutaneous injection,
20 mg/kg/d
for 17 d		 Isoflurane Unclear 21–25 d after injury 4
Wu et al., 2008 [10] Male
Wistar rats		 CCI (1) TBI + saline (n = 8)
(2) TBI + simvastatin (n = 8)		 Orally,
1 mg/kg/d
for 14 d		 Chloral hydrate 1 d after injury 31–35 d after injury 7
Jin et al., 2013 [29] Male
Wistar rats		 FPI (1) TBI + saline (n = 12)
(2) TBI + atorvastatin (n = 12)		 Orally,
1 mg/kg/d
for 14 d		 Chloral hydrate Within 1 h after injury 21–25 d after injury 4
Liu, 2009 [30] Male
Wistar rats		 FPI (1) TBI + saline (n = 11)
(2) TBI + simvastatin (n = 13)		 Orally,
20 mg/kg/d,
unclear treatment duration		 Chloral hydrate 1 d after injury 21–25 d after injury 5
Zhang et al., 2012 [31] Male
Wistar rats		 FPI (1) TBI + saline (n = 12)
(2) TBI + atorvastatin (n = 12)
(3) TBI + simvastatin (n = 12)
(4) TBI + rosuvastatin (n = 12)		 Orally,
atorvastatin/simvastatin:
2 mg/kg/d for 21 d,
rosuvastatin: 1 mg/kg/d
for 21 d		 Chloral hydrate Within 1 d after injury 22–28 d after injury 5

Note: CCI: controlled cortical impact; FPI: fluid percussion injury; CHI: closed head injury.