Table 1.
Protection of mitochondria and improvement of energy metabolism during MIRI.
Pharmacological action | Methods | Reference |
---|---|---|
Protect mitochondria and improve energy metabolism | Reduce myocardial ATP delay ATP breakdown | Nordlie et al. 2006 [5] |
Protect Na+-K+-ATPase activity | Wang et al. 2003 [6] | |
Stimulate synthesis of protein and RNA | Zhu et al. 2010 [7] | |
Maintain the complete structure of biological membranes and myocardial fibers | Shi et al. 1998 [8] | |
Reduce SDH and CCO deactivation | Wang et al. 1998 [9] | |
Increase activity of Ca2+-ATPase and Ca2+-Mg2+-ATPase and regulate expression of the Bcl-2 gene | Wan et al. 2001 [10] |