Table 3.
Percent difference (95% confidence interval) in cord serum total cholesterol by increasing quartile of selenium or copper, THREE study 2004–2005, n = 274
| Model | Q1 | Q2 | Q3 | Q4 | Test for trenda |
|---|---|---|---|---|---|
| Selenium (μg/l) | 42.0–62.0 | 63.0–69.0 | 70.0–78.0 | 79.0–114.0 | |
| Model 1b | 1.00 (referent) | 2.7 (−5.8, 11.9) | 3.3 (−5.3, 12.6) | 6.4 (−2.7, 16.2) | 0.038 |
| Model 2c | 1.00 (referent) | 3.4 (−5.2, 12.8) | 2.5 (−6.2, 11.9) | 7.9 (−1.7, 18.5) | 0.035 |
| Model 3cd | 1.00 (referent) | 2.3 (−6.3, 11.7) | 1.0 (−7.7, 10.5) | 4.9 (−5.2, 16.2) | 0.132 |
| Copper (μg/dl) | 12.1–28.4 | 28.5–38.0 | 38.1–51.6 | 51.7–109.0 | |
| Model 1b | 1.00 (referent) | 1.4 (−7.1, 10.7) | 7.2 (−1.9, 17.3) | 3.0 (−6.0, 12.8) | 0.222 |
| Model 2c | 1.00 (referent) | 2.1 (−6.6, 11.5) | 10.6 (0.8, 21.3) | 6.7 (−3.2, 17.6) | 0.062 |
| Model 3dd | 1.00 (referent) | 1.2 (−7.4, 10.6) | 8.0 (−2.0, 19.2) | 3.9 (−6.3, 15.2) | 0.254 |
THREE, Tracking Health Related to Environmental Exposures; Q1, first quartile; Q2, second quartile; Q3, third quartile; Q4, fourth quartile; HUFA, highly unsaturated fatty acid.
a
Based on regression model using selenium or ln(copper) instead of quartiles.
b
Adjusted for gestational age (quadratic).
c
Adjusted for gestational age (quadratic), maternal age, maternal race, maternal smoking, primiparity, low birth weight, prepregnancy body mass index (quadratic), n-3 HUFAs/total HUFAs and ln(methyl mercury).
d
Adjusted for variables in model 2 as well as either (3c) ln (copper) or (3d) selenium.