Figure 3. Humoral immune responses are reduced in mice depleted of langerin⁺ cells prior to skin vaccination.

Anti-influenza binding antibodies were determined by ELISA in sera collected from DT+ and DT− mice 14 and 28 days after immunization. (A) IgG, (B) IgG1 and (C) IgG2c antibody titers. (D) IgG1/IgG2c antibody ratios. Values are expressed as mean +/− SEM (n ≥ 15).