Figure 1.

Src activation. The activation of Src requires a switch from an inactive to an active conformation. This corresponds to a phosphorylation switch from a tyrosine residue located in the regulatory C-terminal tail (Y530), which is characteristic of the inactive state, to a tyrosine residue located in the catalytic SH1 domain (Y419). Src activation can result from various extra- and/or intracellular signals.