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Catechol-O-methyltransferase (COMT) enzyme activity measured 4 h after treatment (placebo or tolcapone)
| CMT genotype |
Drug | COMT activity (cpm/mg protein) |
|
|---|---|---|---|
| Mean ± SD | Range | ||
| Val/Val | Placebo | 194606.8 ± 33248.95 | 166183.6–240754.2 |
| Val/Val | Tolcapone | 162443.3 ± 42447.9 | 98857.8–186635.7 |
| Val/Met | Placebo | 106242.8 ± 36605.0 | 79724.1–166394.7 |
| Val/Met | Tolcapone | 97566.0 ± 39667.6 | 64850.6–165318.1 |
| Met/Met | Placebo | 47434.5 ± 11837.6 | 29641.5–61988.2 |
| Met/Met | Tolcapone | 51938.4 ± 13999.1 | 38355.1–82681.4 |
