TABLE 2.
Graft survival and histopathology at time of graft failure
| Exp | Antibody deposition | Complement deposition | Cellular Infiltrate | Thrombotic Microangiopathy |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| IgM | IgG | C3 | C4d | C5b-9 | T cells | B cells | MΦ | Neut | Fibrin deposition |
Platelets | |
| 1 | ( + ) | ( + ) | ( + ) | ( −− ) | ( −− ) | ( −− ) | ( −− ) | ( + ) | ( + ) | ( −− ) | ( −− ) |
| 2 | ( + + + ) * | ( + + + ) * | ( ++ ) | ( + ) | ND | ( −− ) | ( −− ) | ( −− )* | ( + + + ) | ( + + + ) | ( + + ) |
| 3 | ( + + + ) * | ( + + + ) * | ( + ) | ( + ) | ( + ) | ( −− ) | ( −− ) | ( −− )* | ( + + + ) | ( + + + ) | ( + + ) |
| 4 | ( + + + ) | ( −− ) | ( + + + ) | ND | ND | ( + ) | ( + ) | ( + + ) | ( + + + ) | ( + + + ) | ( + + + ) |
| 5 | ( + + + ) * | ( + + + ) * | ( + ) | ( + ) | ( + ) | ( −− ) | ( −− ) | ( + ) | ( + + + ) | ( + + + ) | ( + + ) |
| 6 | ( + ) | ( −− ) | ( −− ) | ND | ND | ( + ) | ( + ) | ( +++ ) | ( + + + ) | ( + + + ) | ( + + ) |
| 7 | ( −− ) | ( −− ) | ( −− ) | ND | ND | ( + ) | ( + ) | ( + ) | ( ++ ) | ( + + + ) | ( + + ) |
| 8 | ( + + ) | ( + ) | ( + + + ) | ( + + ) | ND | ( −− ) | ( −− ) | ( + ) | ( + + + ) | ( + + + ) | ( + + ) |
| 9 | ( + + + ) * | ( + + + ) * | (++ ) | ( + ) | ND | ( −− ) | ( −− ) | ( ++ ) | ( + + + ) | ( + + + ) | ( + + + ) |
| 10 | ( + + ) | ( + + ) | ( + ) | ( −− ) | ND | ( −− ) | ( −− ) | ( −− ) | ( + ) | ( + + + ) | ( + + + ) |
| 11 | ( + + ) | ( + + ) | ( + + ) | ( −− ) | ( −− ) | ( + ) | ( + ) | ( + + + ) | ( + ) | ( + + ) | ( + + ) |
| 12 | ( + + + ) | ( + ) | ( + + + ) | ( + + ) | ND | ( + ) | ( + ) | ( + ) | ( + + + ) | ( + + + ) | ( + + + ) |
(−−) none; (+) mild; (++) moderate; (+++) severe.
h = hours; d = days; w = weeks.
MΦ = macrophages; Neut = neutrophils
*
IgM deposition: Intensive in large vessels and less severe in the interstitial capillaries.
IgG deposition: Intensive in interstitial capillaries and less severe in the large vessels.
**
monocytes/macrophages seen in the vessels only.