Table 2.
Results of the multiple variable Cox proportional hazards analysis for selected predictors of recurrent Clostridium difficile infection in outpatients.
| Variable | Hazard Ratio | 95% Confidence Interval | p-value |
|---|---|---|---|
| Male | 0.9 | 0.5 -1.7 | 0.77 |
|
| |||
| Age1 | 1.1 | 0.9-1.3 | 0.22 |
|
| |||
| Weighted Charlson Comorbidity index | |||
| =0 | 1.0 (reference) | ||
| =1 | 0.7 | 0.1-3.1 | 0.59 |
| >1 | 0.9 | 0.3 -2.9 | 0.87 |
|
| |||
| Peripheral WBC count > 15×109/L 2 | 1.0 | 0.5-2.1 | 0.92 |
|
| |||
| Serum creatinine increase 3 | 0.8 | 0.4 -1.5 | 0.44 |
|
| |||
| First episode of CDI was severe-complicated | 0.8 | 0.3-2.1 | 0.70 |
|
| |||
| Antibiotic use4 | 5.4 | 1.6-17.5 | 0.005 |
|
| |||
| Narcotic use5 | 1.0 | 0.5-1.8 | 0.93 |
|
| |||
| H2 blockers or PPI use5 | 0.9 | 0.5 -1.6 | 0.65 |
|
| |||
| Antimotility use5 | 1.1 | 0.5-2.5 | 0.74 |
1
Age was treated as a continuous variable and studied in 10 year intervals
2
Peripheral white blood cell count was dichotomized as ≥15 × 109/L or <15 × 109/L
3
Increase in serum creatinine was dichotomized as ≥1.5 fold or <1.5 fold compared to baseline
4
Antibiotic use 30 days after first CDI diagnosis
5
Medication use was examined from 7 days prior to, to 30 days after, initial CDI diagnosis