Table 2. Nonsense mutations described in HDGC, LBC families and EODGC cases that could be targeted by suppressor-tRNAs (full data in Supplementary Material).

Gene domain	Protein domain	CDH1 mutation	Normal codon	Original amino acid	Generated PTC
HDGC
Exon 2	Signal	c.59G>A	TGG	Trp	TAG
Exon 2	Signal	c.70G>T	GAG	Glu	TAG
Exon 3	Precursor	c.187C>T	CGA	Arg	TGA
Exon 3	Precursor	c.190C>T	CAA	Gln	TAA
Exon 3	Precursor	c.283C>T	CAG	Gln	TAG
Exon 4	Precursor	c.489C>A	TGC	Cys	TGA
Exon 5	Extracellular	c.586G>T	GGA	Gly	TGA
Exon 7	Extracellular	c.1003C>T	CGA	Arg	TGA
Exon 8	Extracellular	c.1023T>G	TAT	Tyr	TAG
Exon 10	Extracellular	c.1507C>T	CAG	Gln	TAG
Exon 12	Extracellular	c.1792C>T	CGA	Arg	TGA
Exon 12	Extracellular	c.1913G>A	TGG	Trp	TAG
Exon 13	Extracellular	c.2095C>T	CAG	Gln	TAG
Exon 14	Cytoplasmic	c.2275G>T	GGA	Gly	TGA
Exon 14	Cytoplasmic	c.2287G>T	GAG	Glu	TAG
EODGC
Exon 12	Extracellular	c.1792C>T	CGA	Arg	TGA
LBC
Exon 3	Precursor	c.283C>T	CAG	Gln	TAG

Abbreviations: Arg, arginine; Cys, cysteine; Gln, glutamine; Glu, glutamic acid; Gly, glycine; TAA, ochre; TAG, amber; TGA, opal; Trp, tryptophan; Tyr, tyrosine.