Table 2. Competitive gene-set analysis of the genetic variation in the nine sub-processes of DNA-damage response and DNA repair in relation to human longevity.

	Setup
	I – χ2		II – trend test		III – best-test model
Sub-processes	P-value	q-value	P-value	q-value	P-value	q-value
DmgRes	0.113	0.171	0.475	0.556	0.299	0.447
BER	0.015	0.110	0.029	0.121	0.016	0.111
NER	0.679	0.681	0.556	0.563	0.679	0.681
MMR	0.434	0.553	0.498	0.556	0.686	0.681
HRR	0.035	0.110	0.004	0.030	0.025	0.111
NHEJ	0.099	0.171	0.163	0.286	0.112	0.231
RECQ	0.032	0.110	0.048	0.159	0.049	0.160
TeloFunc	0.076	0.159	0.077	0.163	0.130	0.231
MitoDNA	0.616	0.681	0.439	0.556	0.608	0.681

Abbreviations: BER, base excision repair; DmgRes, DNA-damage response; HRR, homologous recombinational repair; MitoDNA, mitochondrial DNA processes; MMR, mismatch repair; NER, nucleotide excision repair; NHEJ, non-homologous end-joining; RECQ, RecQ helicase activities; TeloFunc, telomere functioning.

P- and q-values <0.05 are shown in bold.