. Author manuscript; available in PMC: 2014 Aug 18.

Published in final edited form as: Sci Signal. 2013 Aug 27;6(290):ra73. doi: 10.1126/scisignal.2004184

Table 1. Summary of the effects of cholesterol extraction on the coupling of CaCC activity to BK- and PAR-2-induced Ca²⁺ release and to VGCC-mediated Ca²⁺ influx.

Numbers represent amount of neurons displaying a given property from the total amount of neurons tested for each condition. Significant differences based on χ² with p < 0.05 are indicated. N/A, not analyzed

Property:	No treatment (Control)		βMCD		αCD
BK-induced cytosolic Ca²⁺ transients	18/31		13/31		N/A
BK-induced CaCC current	16/35		1/15^*		7/14
PAR2-PL-induced CaCC current	8/15		1/16^*		8/16
CaCC tail current after VGCC activation	1/20		10/20^*		1/21^$
Multiple AP firing	High [Cl⁻]_i			Low[Cl⁻]_i
Multiple AP firing	3/18	11/22^*		3/19^#	2/15^&

significantly different from control;

significantly different from βMCD;

significantly different from high [Cl⁻]_i;

significantly different from βMCD with high [Cl⁻]_i

Table 1. Summary of the effects of cholesterol extraction on the coupling of CaCC activity to BK- and PAR-2-induced Ca2+ release and to VGCC-mediated Ca2+ influx.

Table 1. Summary of the effects of cholesterol extraction on the coupling of CaCC activity to BK- and PAR-2-induced Ca²⁺ release and to VGCC-mediated Ca²⁺ influx.