Table 2. Levels ± SEM of plasma chemokines and cytokines of Balb/c wild-type or Balb/c caspase-1 KO mice six months following exposure to PBS or pristine.

MCP-1=monocyte chemoattractant protein 1/CCL2; MIP1α=macrophage inflammatory protein 1α/CCL3; IP-10=interferon gamma-induced protein-10/CXCL10; CCL=chemokine ligand; GMCSF=granulocyte macrophage colony stimulating factor; IFN=interferon; IL=interleukin; TNF=tumor necrosis factor. PBS WT n=6, PBS −/− n=11, Pristane WT n=13, Pristane −/− n=24.

Cytokine	Wild Type PBS (pg/ml)	Wild Type Pristane (pg/ml)	WT PBS vs Pristane p value	Casp-1 −/− PBS (pg/ml)	Casp-1 −/− Pristane (pg/ml)	Casp-1 −/− PBS vs Pristane p value	WT pristane vs KO pristane p value
MCP-1	36±10.37	174.8±25.86	0.0024	78.36±78.36	124.4±16.1	0.0251	0.0856
MIP1α	9.5±5.051	45±10.57	0.0105	1.83±1.273	14.23±2.425	0.0004	0.0009
IP-10	205±49.12	332.8±29.11	0.0393	163.7±25.16	335.8±42.63	0.0007	NS
CCL5/rantes	18.17±5.474	18.92±3.68	NS	51.09±27.07	63.67±25.35	NS	0.0371
GMCSF	75.17±18.4	85.00±25.38	NS	53.40±16.45	80.08±25.13	NS	NS
IFN-ɣ	0.6667±0.494	0.6154±0.368	NS	0.8000±0.467	1.292±0.682	NS	NS
IL-1β	9.000±4.025	4.154±2.189	NS	8.900±3.761	3.167±1.788	NS	NS
IL-2	26.83±7.639	19.46±8.883	NS	8.545±4.137	7.875±2.23	NS	NS
IL-4	0	.07692±0.077	NS	0	0	NS	NS
IL-5	4.5±2.986	11.23±3.327	NS	9.273±4.083	6.833±2.103	NS	NS
IL-10	0	0	NS	11.18±11.18	11.79±9.548	NS	NS
IL-12p40	27.33±9.535	57.62±42.07	NS	42.45±11.89	80.21±53.55	NS	NS
IL-12p70	5.333±2.894	261.6±229.8	NS	2.545±1.065	11.13±8.632	NS	NS
TNF-α	2.5±1.586	4.615±1.357	NS	4.182±1.536	3.25±0.7	NS	NS