TABLE 2 .

Reported hazards of combined hormone replacement therapy (CHRT) by the Women's Health Initiative

Hazards of CHRT	% Increase
Invasive breast cancer (Rossouw et al. 2002; Manson et al. 2013)	+26, +28
Increase in total cardiovascular mortality (Rossouw et al. 2002) (despite improved lipid profiles)	+22
Increase in “heart attacks” (Rossouw et al. 2002)	+29
Pulmonary emboli (Shumaker et al. 2003)	+113
Probable dementia for women >65 yrs old (Shumaker et al. 2003)	+105
Abnormal mammograms (Chlebowski et al. 2003)	+74
Ovarian cancer (Anderson et al. 2003)	+58
Breast cancer mortality (near doubling) (Chlebowski et al. 2003)	+96
Stroke occurrence (Rossouw et al. 2002)	+41