FIGURE 5.

Random-effects meta-analysis comparing effects of a hypercaloric fructose diet with a hypercaloric glucose diet (neutral energy comparison) on liver fat measured by IHCLs ¹H MRS. Each black box represents the individual study's effect estimate, and the horizontal line represents the 95% CI of the effect estimate. The diamond shape represents the meta-analysis pooled effect estimate and its CI. A vertical dashed line displays the location of the meta-analysis pooled effect estimate. IHCL, intrahepatocellular lipid; IHCLs ¹H MRS, intrahepatocellular lipids by proton magnetic resonance spectroscopy; RCT, randomized controlled trial; ROB, risk of bias; %Change, net percentage change in intrahepatocellular lipids from baseline between groups; %signal, percent signal; %vol, percent volume.