TABLE 1.
Pkd1 mouse lines
| Mouse line | Genetic modification | Description | Reference |
|---|---|---|---|
| Pkd1V/V | Knock-in | T3041V at GPS/GAIN domain produces noncleavable Pc1V | 26 |
| Pkd1extra2 | Transgenic (∼80 copies) | F3043X in Pkd1-BAC produces NTF-like protein | 44 |
| Pkd1extra39 | Transgenic (∼2 copies) | F3043X in Pkd1-BAC produces NTF-like protein | 44 |
| Pkd1TAG26 | Transgenic (∼15 copies) | Full-length Pkd1WT-BAC overexpresses endogenous Pc1 | 43 |
| Pkd1m1Bei/m1Bei | ENU mutagenesis | M3083R within the first transmembrane domain of CTF | 42 |
| Pkd1MYC/MYC | Knock-in | Produces fully functional Pc1 with a C-terminal 5×Myc tag | 45 |
| Pkd1ΔCMYC/ΔCMYC | Knockout | Produces 5×Myc-tagged Pc1 lacking C-terminal 257 aa | 45 |