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. 2014 Sep;34(17):3305–3320. doi: 10.1128/MCB.00677-14

FIG 1.

FIG 1

Nrf2−/− mice on an HF diet exhibit reduced adiposity and higher energy expenditure than Nrf2+/+ mice. (A and B) Body mass curves of male age-matched Nrf2+/+ and Nrf2−/− mice fed on an RC (A) or HF (B) diet for 20 weeks from 8 weeks of age (10 or 11 mice per group). (C) Body mass gains of Nrf2+/+ and Nrf2−/− mice fed on an HF diet. (D) Percentages of body fat in Nrf2+/+ and Nrf2−/− mice on an RC or HF diet (12 or 13 mice per group). (E) Cumulative food intake of age-matched male Nrf2+/+ and Nrf2−/− mice fed on RC over a period of 20 weeks (6 mice per group). (F) Food intake after overnight fast in age-matched Nrf2+/+ and Nrf2−/− mice fed on an HF diet (5 mice per group). (G and H) Fed plasma leptin (G) and insulin (H) levels from Nrf2+/+ and Nrf2−/− mice on an RC or HF diet (9 to 11 mice per group). (I and J) RER (I) and oxygen consumption (J) (the lines show fitted regressions) for Nrf2+/+ and Nrf2−/− mice on an RC or HF diet (7 to 13 mice per group). (K) Effects of genotype and diet on locomotor activity for Nrf2+/+ and Nrf2−/− mice (7 to 13 mice per group). (D, G to I, and K) White bars, RC fed; black bars, HF fed. The results are means and SEM. *, P < 0.05; **, P < 0.01; ***, P < 0.001.