FIG 1.
Microarray screening of related lncRNAs using SGC7901/ADR and SGC7901/VCR sublines. (A) SGC7901/ADR and SGC7901/VCR sublines were induced by the parental gastric adenocarcinoma cell line SGC7901 using ADR and vincristine, respectively. (B) lncRNA microarrays covered 18,534 lncRNAs and were used to identify MDR-related lncRNAs. When expression profiles were compared between SGC7901/VCR and SGC7901 and between SGC7901/ADR and SGC7901, 1,418 and 1,497 differentially expressed lncRNAs were identified, respectively; of these, SGC7901/VCR and SGC7901/ADR shared 625 differentially expressed lncRNAs (lncRNA-Cs). GES-1 is the immortalized normal gastric epithelial cell line. (C) lncRNA-Cs (fold change, ≥4.0). (D) lncRNA-Cs (fold change, ≥4.0) surrounded by drug resistance-related genes reported in multiple tumors and the corresponding drug resistance-related genes.