FIG 8.
A model for the role of GR SUMOylation in the modulation of cross talk between glucocorticoid signaling and other transcription factors involved in stress and inflammation. (A) Activated GR results in the repression seen with AP1, NF-κB, HSF1, HIF1A, ATF4, and NRF2. (B) 15d-PGJ2 activates NRF2. It also triggers the hyper-SUMOylation of GR, resulting in alleviation of the GR-mediated repression of the cell stress-associated transcription factors. Green oval, inhibition; red oval, activation; arrow, activation; arrow with a blunt end, inhibition.