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Proposed model for CHIP-mediated ubiquitination and degradation of MLK3. GA or stress stimuli promote MLK3-Hsp90 dissociation, and MLK3 subsequently interacts with Hsp70. Hsp70 recruits CHIP, which, together with E1, E2 (UbcH5), and ubiquitin, promotes polyubiquitination of MLK3. Polyubiquitinated MLK3 undergoes proteasome-mediated degradation.
