TABLE 4.
Statistical correlation between nts1-regulated genes and genes that directly overlap with Tf2 LTRs and solo LTRs or are found within 500 bp of these elementsa
| Up- or downregulation | No. of genes associated with LTRs |
P value |
Median no. of genes randomly associated with LTRs (1,000 permutations) |
|||
|---|---|---|---|---|---|---|
| Direct | 500 bp | Direct | 500 bp | Direct | 500 bp | |
| nts1+ O/E ↓ | 14 | 17 | 2.23 × 10−11 | 4.40 × 10−5 | 1 | 1 |
| nts1Δ ↑ | 16 | 34 | 3.49 × 10−12 | 8.82 × 10−15 | 1 | 1 |
| nts1Δ ↑ nts1+ O/E ↓ | 16 | 18 | 6.82 × 10−21 | 1.04 × 10−12 | 0 | 0 |
a
Direct, genes that directly overlap with Tf2 LTRs and solo LTRs; 500 bp, genes found within 500 bp of Tf2 LTRs. The median number of nucleus-encoded genes that randomly intersect with Tf2 LTRs or are found within 500 bp of these loci is also shown.