FIG 5.

IRS proteins mediate the metabolic response to exercise training. (a to c) Palmitate oxidation, glucose oxidation, and glycolysis rates in isolated working WT, CIRS1KO, and CIRS2KO hearts under sedentary conditions and following chronic exercise training (n = 6 to 10). Hearts were perfused with 5 mmol/liter glucose and 0.4 mmol/liter palmitate. (d) Cardiac glycogen content as indicated (n = 7 to 8). Data are presented as fold changes compared to sedentary controls (same genotype); †, P < 0.05 versus sedentary (same genotype).