TABLE 2.
List of dinB intragenic suppressor alleles
| Allele | Missense mutation | Structure areab | Catalytic activity in vivo/in vitro | Allele no.a |
|---|---|---|---|---|
| dinB(V7G) | T to G | 1 | Yes/yes | dinB68 |
| dinB(P182L) | C to T | 1 | NKd | dinB69 |
| dinB(S226R) | A to C | 1 | NK | dinB70 |
| dinB(L266R) | T to G | 2 | NK | dinB71 |
| dinB(V288G)c | T to G | 2 | No/insoluble | dinB72 |
| dinB(K291E) | A to G | 2 | NK | dinB73 |
| dinB(F292Y) | T to A | 2 | Yes/yes | dinB74 |
| dinB(T299I) | C to T | 2 | NK | dinB75 |
| dinB(L307Q) | T to A | 2 | NK | dinB76 |
| dinB(R323C) | C to T | 2 | NK | dinB77 |
| dinB(L349P) | T to C | 2 | NK | dinB78 |
| dinB(L351S) | T to C | 2 | NK | dinB79 |
a
Allele numbers are assigned by the Coli Genetic Stock Center at Yale University.
b
1, area surrounding the catalytic core of the protein; 2, not catalytic area of the protein.
c
The V228G amino acid substitution independently arose in multiple isolates.
d
NK, not known.