TABLE 3.
dinB alleles and phenotypes
| Allele | Phenotypej of strain carrying: |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
dnaE+ |
dnaE915 |
|||||||||
| On chromosome and treated with: |
On low-copy-no. plasmid and treated with: |
OEg | On chromosome and treated with: |
On low-copy-no. plasmid and treated with: |
OE | |||||
| NFZh | MMSi | NFZ | MMS | NFZ | MMS | NFZ | MMS | |||
| ΔdinB | Sa | Sb | Sa,e | Sb,e | —f | S | S | — | — | — |
| dinB+ | Ra | Rb | Ra | Rb | Tc | R | R | R | HS | T |
| dinB(D103N) | Sd | Sd | HSa | HSd | T | HS | HS | HS | HS | T |
| dinB(D103NΔβ) | ND | ND | Sd | Sd | ND | ND | ND | S | S | ND |
| dinB(V288G) | ND | ND | S | S | ND | ND | ND | S | S | ND |
| dinB(F292Y) | ND | ND | R | R | RT | ND | ND | R | S | RT |
| dinB(V7G) | ND | ND | R | R | RT | ND | ND | R | R | RT |
a
See reference 13.
b
See reference 16.
c
See reference 18.
d
See reference 14.
e
Vector alone.
f
—, not applicable.
g
OE, overexpressed.
h
NFZ, nitrofurazone.
i
MMS, methyl methanesulfonate.
j
R, resistant, full growth; S, sensitive, at least 10-fold-fewer CFU than dinB+ strain; HS, hypersensitive, fewer CFU than ΔdinB strain or ΔdinB strain with vector; T, toxic, overexpression results in at least 100-fold-fewer CFU than strain with chromosomal dinB+; RT, reduced toxicity compared to dinB+; ND, not done.