Table 3. Nuclear stress test results and clinical symptoms at the time of testing.

	MED (N = 767)	REV (N = 738)	P value
Revascularization since randomization	16.2%	97.8%	<.001
Myocardial infarction since randomization	3.8%	5.4%	.002
CCS class, at the time of testing			.06
0	57.8%	64.8%
1-2	20.5%	14.9%
3-4	1.5%	1.1%
Unstable + acute MI	1.5%	1.3%
Unknown	18.7%	17.9%
Adenosine stress myocardial perfusion SPECT results
Chest pain	75.2%	75.2%	.99
Electrocardiographic changes			.63
No ST depression	66.1%	67.9%
Equivocal ST segment changes<1 mm	19.4%	17.3%
ST segment depression ≥1 mm	14.2%	14.8%
Post-stress LVEF, mean, SD	58.6, 11.1	58.0, 11.9	.31
LVEF subsets			.23
≥50%	82.2%	80.3%
40%-49%	12.2%	11.8%
<40%	5.6%	7.9%
Any wall motion abnormality	25.0%	27.0%	.39
Myocardial perfusion SPECT abnormalities			<.001
0 segments	38.3%	47.0%
1-2 segments	17.5%	13.4%
3-5 segments	31.0%	27.8%
≥6 segments	13.2%	11.8%
Ischemia extent			<.001
0 segments	48.8%	58.8%
1-2 segments	18.9%	15.7%
3-5 segments	24.3%	21.4%
≥6 segments	8.0%	4.1%
Territory of severely abnormal MPS
Left anterior descending	24.4%	21.4%	.17
Right coronary artery	34.9%	28.4%	.007
Left circumflex	18.3%	17.9%	.83
Quantitative % myocardium
% Abnormal, median (25–75th %ile)	9 (0–19)	3 (0–12)	.01
% Ischemic, median (25–75th %ile)	2 (2–10)	0 (0–7)	<.001
% Scarred, median (25–75th %ile)	0 (0–8)	0 (0–1)	.85
Semi-quantitative measures—summed scores
Summed stress score, mean, SD	47.2, 4.8	47.3, 5.6	.52
Severe stress abnormality*	61.5%	52.9%	<.001
Summed rest score, mean, SD	49.3, 3.6	49.0, 4.7	.08
Severe rest abnormality*	30.5%	30.9%	.87
Summed difference score (SDS), mean, SD	2.2, 3.0	1.6, 2.7	<.001
Severe ischemia*	51.0%	41.1%	<.001

CCS, Canadian Cardiovascular Society; LVEF, left ventricular ejection fraction; MPS, myocardial perfusion SPECT.

^*Severe abnormalities defined semi-quantitatively as ≥10% of the myocardium.