Table 2.

Coronary heart disease incidence and mortality rates and adjusted hazard ratios (95% CI) for the association of diabetes with CHD incidence and mortality in 1987–1996 and in 2003–2009.

	1987–1996		2003–2009		p-value interaction
	No Diabetes	Diabetes	No Diabetes	Diabetes
N	13,152	1,673	10,415	2,297
CHD incidence
Incidence rate* (95% CI)	3.9 (3.5, 4.4)	11.1 (9.3, 13.2)	2.2 (1.8, 2.7)	5.4 (4.2, 7.0)	---
Model 1†	1 (ref)	2.83 (2.29, 3.49)	1 (ref)	2.44 (1.78, 3.34)	0.39
Model 2‡	1 (ref)	1.95 (1.56, 2.43)	1 (ref)	2.23 (1.60, 3.13)	0.33
Model 3§	1 (ref)	1.99 (1.59, 2.49)	1 (ref)	2.39 (1.69, 3.35)	0.95
CHD mortality
Mortality rate* (95% CI)	0.8 (0.7, 1.1)	4.3 (3.2, 5.7)	0.4 (0.3, 0.6)	1.3 (0.9, 1.9)	---
Model 1†	1 (ref)	5.21 (3.58, 7.58)	1 (ref)	2.90 (1.73, 4.87)	0.09
Model 2‡	1 (ref)	3.43 (2.30, 5.11)	1 (ref)	2.89 (1.66, 5.04)	0.08
Model 3§	1 (ref)	3.45 (2.31, 5.14)	1 (ref)	3.21 (1.81, 5.63)	0.21

CHD: coronary heart disease; CI: confidence interval; p-value for interaction of diabetes status and time period

^*Rates are per 1,000 person-years and adjusted for age, race, and sex

^†Model 1: adjusted for age, race, and sex

^‡Model 2: adjusted for age, race, sex, high-density lipoprotein cholesterol, systolic blood pressure, antihypertensive medication use, current smoking, and body mass index

^§Model 3: adjusted for model 2 variables plus lipid-lowering medication use and low-density lipoprotein cholesterol