FIG 2.

Interplay of Hst 5 treatment with MAPK pathways of C. albicans. Activation of Cek1 MAPK by environmental conditions such as GlcNAc as a carbon source or growth temperature of 37°C may potentially enhance Hst 5 susceptibility by Cek1-mediated cell wall modifications (left). On the other hand, Hst 5 treatment itself causes oxidative stress, leading to the activation of Hog1 stress MAPK in C. albicans (right). Inhibition of Cek1 pathway by Hog1 activation offers another layer of complexity to this interplay between Hst 5 treatment and cellular MAPK pathways. Proteins that are phosphorylated are indicated by a blue P.