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NS5A amino acid substitutions in cDNA clones isolated from DCV-treated GT-5a replicon cells
| Replicon | Amino acid substitution(s) | No. of clones with indicated substitution at DCV selection concn of: |
|
|---|---|---|---|
| 1 nM | 10 nM | ||
| GT-5a-7 | L31F | 15 | 17 |
| L31V | 3 | 0 | |
| L31F-K56R | 2 | 11 | |
| L31V-K56R | 1 | 0 | |
| Total no. of clones | 21 | 28 | |
| GT-5a-9 | |||
| L31F | 9 | NAa | |
| L31V | 12 | NA | |
| Total no. of clones | 21 | NA | |
NA, not applicable.
