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Susceptibility of GT-5a replicon variants to DCV
| Parent or variant | EC50 (nM)a | Fold resistance |
|---|---|---|
| GT-5a-7 (parent) | 0.0048 ± 0.0005 | 1 |
| GT-5a-7 L31F | 6.9 ± 1.0 | 1,438 |
| GT-5a-7 L31V | 2.2 ± 0.81 | 458 |
| GT-5a-7 K56R | 0.012 ± 0.0013 | 3 |
| GT-5a-7 L31F-K56R | 39.3 ± 13.1 | 8,188 |
| GT-5a-7 L31V-K56R | 29.4 ± 2.2 | 6,125 |
| GT-5a-9 (parent) | 0.0031 ± 0.0005 | 1 |
| GT-5a-9 L31V | 2.2 ± 0.05 | 710 |
Values are means ± standard deviations obtained from Huh-7 cells harboring the indicated GT-5a replicon variants (n ≥ 3).
