TABLE 1.
H. capsulatum form | Parameter(μg/ml) | Data for antibiotica: |
|||||||
---|---|---|---|---|---|---|---|---|---|
AMB | ITC | VRC | POS | ISA | CASb | FLU | 5-FC | ||
Mycelial | GM | 0.11 | 0.043 | 0.102 | 0.05 | 0.055 | 0.097 | 7.05 | 64 |
MIC50/MEC50 | 0.125 | 0.03 | 0.125 | 0.06 | 0.06 | 0.125 | 8 | 32 | |
MIC90/MEC90 | 0.25 | 0.125 | 0.25 | 0.125 | 0.25 | 0.25 | 16 | >64 | |
Range | 0.03 to 0.25 | <0.03 to 0.125 | <0.03 to 0.25 | 0.015 to 0.125 | 0.015 to 0.25 | 0.015 to 0.5 | 2 to 32 | 8 to >64 | |
Yeast | GM | 0.13 | 0.051 | 0.17 | 0.085 | 0.04 | 0.17 | 4.56 | 48.2 |
MIC50 | 0.125 | 0.06 | 0.25 | 0.06 | 0.06 | 0.25 | 4 | 16 | |
MIC90 | 0.25 | 0.125 | 0.5 | 0.25 | 0.125 | 0.5 | 8 | 64 | |
Range | 0.03 to 0.5 | 0.03 to 0.25 | 0.03 to 0.5 | 0.03 to 0.5 | 0.015 to 0.125 | 0.03 to 1 | 2 to 8 | 8 to 64 | |
Essential agreement (%)c | 100 | 100 | 100 | 87 | 100 | 96 | 100 | 100 |
AMB, amphotericin B; ITC, itraconazole; VRC, voriconazole; POS, posaconazole; ISA, isavuconazole; CAS, caspofungin; FLU, fluconazole; 5-FC, flucytosine.
For caspofungin, the minimal effective concentration (MEC) was read for testing the mycelial form.
MIC discrepancies of more than two dilutions were used to calculate the essential agreement.