FIG 4.

Efficacy of peptides in the S. aureus-infected mouse model. BALB/c mice were infected with 1 × 10⁷ CFU S. aureus strain 33591 by i.p. injection, and antimicrobial drug was administered after 1 h. Bacterial loads in the peritoneal lavage fluid from individual mice after 20 h of infection are shown. (a) 20 mg/kg DP7 administered by i.p., i.m., s.c., or i.v, injection. For controls, 20 mg/kg vancomycin or normal saline was administered by i.p. injection. (b) Peptides (20, 40, and 60 mg/kg), vancomycin (20 mg/kg), and normal saline were administered by i.p. injection. Horizontal bars show standard deviations. *, P < 0.05; **, P < 0.01 (peptide versus normal saline control). #, P < 0.05 (60 mg/kg DP7 versus 60 mg/kg HH2).