TABLE 2.
Vancomycin population analysis during induction phase for clinical strains
| Strain | No. of days | Antibiotic exposure | AUC (log10[CFU/ml] × mg/liter) | Day 18 AUC/day 0 AUC (%) | Growth on 4 mg/liter VAN | AUC/Mu3 AUC (%) |
|---|---|---|---|---|---|---|
| FOU | 0 | 12.51 | No | 51 | ||
| 18 | Blank | 12.75 | 2 | No | 52 | |
| 18a | VAN | 23.61 | 89 | Yes | 97 | |
| 18 | IPM | 20.99 | 68 | Yes | 86 | |
| 18 | CAZ | 14.04 | 12 | No | 58 | |
| 18 | CRO | 16.32 | 30 | No | 67 | |
| NAR | 0 | 10.03 | No | 41 | ||
| 18 | Blank | 9.87 | −2 | No | 39 | |
| 18 | VAN | 28.82 | 187 | Yes | 115 | |
| 18 | IPM | 16.39 | 63 | No | 66 | |
| 18 | CAZ | 26.18 | 161 | Yes | 105 | |
| 18 | CRO | 17.74 | 77 | No | 71 | |
| GUA | 0 | 14.1 | No | 58 | ||
| 18 | Blank | 15.21 | 8 | No | 61 | |
| 18 | VAN | 32.71 | 132 | Yes | 131 | |
| 18 | IPM | 23.98 | 70 | Yes | 98 | |
| 18 | CAZ | 17.15 | 22 | No | 69 | |
| 18 | CRO | 24.69 | 75 | Yes | 10 |
a
Data for antibiotic-induced strains classified as h-VISA are in bold type.