TABLE 3.
Vancomycin and daptomycin MICs determined initially and after induction phase
| Strain | No. of days | Antibiotic exposure | Vancomycin |
Daptomycin |
||
|---|---|---|---|---|---|---|
| MIC (mg/liter)a | Day 18 MIC/day 0 MIC (mg/liter) | MICa (mg/liter) | Day 18 MIC/day 0 MIC (mg/liter) | |||
| FOU | 0 | 1.5 | 0.064 | |||
| 18 | Blank | 1.5 | 1 | 0.064 | 1.0 | |
| 18 | VANb | 3 | 2 | 0.19 | 3.0 | |
| 18 | IPM | 1.5 | 1 | 0.094 | 1.5 | |
| 18 | CAZ | 1.5 | 1 | 0.125 | 2.0 | |
| 18 | CRO | 2 | 1.3 | 0.19 | 3.0 | |
| NAR | 0 | 1.5 | 0.047 | |||
| 18 | Blank | 1.5 | 1 | 0.064 | 1.4 | |
| 18 | VAN | 4 | 2.7 | 1 | 21.3 | |
| 18 | IPM | 1.5 | 1 | 0.094 | 2.0 | |
| 18 | CAZ | 3 | 2 | 0.25 | 5.3 | |
| 18 | CRO | 2 | 1.3 | 0.19 | 4.0 | |
| GUA | 0 | 2 | 0.094 | |||
| 18 | Blank | 1.5 | 0.75 | 0.094 | 1.0 | |
| 18 | VAN | 4 | 2 | 1 | 10.6 | |
| 18 | IPM | 2 | 1 | 0.094 | 1.0 | |
| 18 | CAZ | 2 | 1 | 0.094 | 1.0 | |
| 18 | CRO | 2 | 1 | 0.19 | 2.0 | |
a
MICs were determined using Etest.
b
Data for antibiotic-induced strains classified as h-VISA are in bold type.