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. 2014 Sep;58(9):5306–5314. doi: 10.1128/AAC.02574-14

TABLE 5.

Nonsynonymous mutations of genes involved in h-VISA resistance

Strain No. of days of treatment Mutation(s)a
vraS vraR yvqF SA17003 graR graS rpoB walK walR
NAR 0 None E59D None None D148Q L26F, I59L, T224I None None None
NAR CAZ (h-VISA) 18 None E59D None None D148Q L26F, I59L, T224I None None None
NAR VAN (h-VISA) 18 None E59D None None D148Q L26F, I59L, T224I None R282Cb None
GUA 0 None None Y128C None None None A477D, G171D None None
GUA CRO (h-VISA) 18 None None Y128C None None None A477D, G171D None None
GUA VAN (h-VISA) 18 None None Y128C None None None A477D, G171D T279I,b S221Pb None
FOU 0 None None None None None None D471Y None None
FOU IPM (h-VISA) 18 None None None None None None D471Y None None
FOU VAN (h-VISA) 18 None None None None None None D471Y K13Rb None
a

Amino acid substitutions are indicated using N315 as a reference.

b

New mutations, which appeared in the course of antibiotic induction.