TABLE 5.
Nonsynonymous mutations of genes involved in h-VISA resistance
Strain | No. of days of treatment | Mutation(s)a |
||||||||
---|---|---|---|---|---|---|---|---|---|---|
vraS | vraR | yvqF | SA17003 | graR | graS | rpoB | walK | walR | ||
NAR | 0 | None | E59D | None | None | D148Q | L26F, I59L, T224I | None | None | None |
NAR CAZ (h-VISA) | 18 | None | E59D | None | None | D148Q | L26F, I59L, T224I | None | None | None |
NAR VAN (h-VISA) | 18 | None | E59D | None | None | D148Q | L26F, I59L, T224I | None | R282Cb | None |
GUA | 0 | None | None | Y128C | None | None | None | A477D, G171D | None | None |
GUA CRO (h-VISA) | 18 | None | None | Y128C | None | None | None | A477D, G171D | None | None |
GUA VAN (h-VISA) | 18 | None | None | Y128C | None | None | None | A477D, G171D | T279I,b S221Pb | None |
FOU | 0 | None | None | None | None | None | None | D471Y | None | None |
FOU IPM (h-VISA) | 18 | None | None | None | None | None | None | D471Y | None | None |
FOU VAN (h-VISA) | 18 | None | None | None | None | None | None | D471Y | K13Rb | None |
Amino acid substitutions are indicated using N315 as a reference.
New mutations, which appeared in the course of antibiotic induction.