TABLE 4.
Summary of PK dataa
| MAb | Cohort | Tmax (day) | Cmax (μg/ml) | AUCinf (μg/day/ml) | t1/2 (days) | Vzb (ml/kg) | CLc (ml/day/kg) |
|---|---|---|---|---|---|---|---|
| Aa | A | 0.05 (0.046, 0.079) | 0.23 (0.23, 0.24) | 2.08 (2.04, 2.1) | 8.9 (8.8, 10.1) | 69 (67, 77) | 5.3 (5.3, 5.5) |
| B | 0.09 (0.084, 0.148) | 1.2 (1.1, 1.23) | 11.63 (9.91, 16.3) | 12.4 (10, 14.1) | 92 (72, 97) | 4.7 (3.4, 5.6) | |
| C | 0.085 (0.083, 0.094) | 2.35 (2.27, 2.88) | 22.09 (20.4, 30.06) | 12.3 (11.3, 13.7) | 88 (82, 93) | 4.9 (3.7, 5.4) | |
| Ab | A | 0.046 (0.046, 0.077) | 0.2 (0.19, 0.21) | 0.66 (0.62, 0.79) | 2.5 (2.3, 2.8) | 59 (56, 65) | 16.6 (14.1, 17.6) |
| B | 0.129 (0.057, 0.17) | 1.16 (1.13, 1.24) | 9.42 (6.86, 12.97) | 12.8 (7.8, 14) | 85 (81, 105) | 5.9 (4.3, 8.2) | |
| C | 0.085 (0.083, 0.094) | 2.62 (2.07, 2.93) | 18.64 (14.43, 21.44) | 10.3 (8.6, 11.3) | 95 (88, 99) | 6 (5, 7.7) | |
| Ac | A | 0.11 (0.048, 0.167) | 0.23 (0.22, 0.24) | 2.9 (2.48, 3.25) | 15.5 (12.1, 21.2) | 87 (79, 112) | 3.8 (3.4, 4.4) |
| B | 0.085 (0.055, 0.091) | 1.19 (1.07, 1.3) | 18.64 (16.01, 23.13) | 26.9 (23.7, 32.1) | 110 (83, 128) | 3 (2.4, 3.5) | |
| C | 0.085 (0.083, 0.144) | 2.4 (2.32, 2.84) | 35.08 (33.33, 41.4) | 24.4 (23.2, 25.5) | 105 (96, 110) | 3.1 (2.8, 3.3) |
a
All data are median (interquartile range).
b
Vz, apparent volume of distribution during terminal phase.
c
CL, clearance.