TABLE 2.
The genotype and vancomycin susceptibilities of the 6R-P-derived colony-size variants
| Strain | Colony sizea | RpoB 512th amino acid | Codon sequenceb | Vancomycin MIC (mg/liter)e |
|---|---|---|---|---|
| Mu3 | LC | Arginined | CGTd | 3 |
| 6R-P | PC | Proline | CCT | 12 |
| L1 | LC | Leucine | CTT | 3 |
| L9-2 | LC | Leucine | CTT | 3 |
| L2 | LC | Serine | TCT | 3 |
| L8 | LC | Serine | TCT | 3 |
| L12-1 | LC | Serine | TCT | 3 |
| L12-2 | LC | Serine | TCT | 3 |
| L3 | LC | Histidine | CAT | 4 |
| L4 | LC | Histidine | CAT | 3 |
| L5-1 | LC | Histidine | CAT | 4 |
| L5-2 | LC | Histidine | CAT | 3 |
| L5-3 | LC | Histidine | CAT | 3 |
| L5-4 | LC | Histidine | CAT | 3 |
| L9-1 | LC | Histidine | CAT | 3 |
| S11 | SC | Proline | CCT | 3 |
| S13 | SC | Proline | CCT | 3 |
| S14-1 | SC | Proline | CCT | 4 |
| S14-2 | SC | Proline | CCT | 3 |
| Mu50 | LC | Argininec | CGT | 12 |
a
LC, large colony; PC, pinpoint colony; SC, small colony.
b
The underlined bases are the changed nucleotides.
c
Mu50 RpoB has a His-to-Tyr amino acid substitution at the 481st codon.
d
Wild type.
e
Determined by Etest after 48 h of incubation.