TABLE 1.
Strain group (no. of strains) and drug | MIC/MEC (μg/ml) |
|||
---|---|---|---|---|
Range | 50% | 90% | Geometric mean | |
Total (n = 46) | ||||
Fluconazole | 8–256 | 32 | 64 | 55.826 |
Flucytosine | 2–256 | 16 | 64 | 32.609 |
Amphotericin B | 2–4 | 4 | 4 | 3.261 |
Itraconazole | 0.25–4 | 0.5 | 2 | 0.973 |
Voriconazole | 0.063–4 | 0.25 | 1 | 0.58 |
Posaconazole | 0.031–1 | 0.125 | 0.5 | 0.232 |
Caspofungin | 2–16 | 8 | 16 | 9.174 |
Micafungin | 0.5–32 | 4 | 16 | 8.63 |
Terbinafine | 0.002–1 | 0.125 | 0.25 | 0.152 |
Clinical (n = 31) | ||||
Fluconazole | 8–256 | 32 | 64 | 43.097 |
Flucytosine | 2–256 | 16 | 64 | 36.387 |
Amphotericin B | 2–4 | 4 | 4 | 3.29 |
Itraconazole | 0.25–1 | 0.5 | 0.5 | 0.476 |
Voriconazole | 0.063–1 | 0.25 | 0.5 | 0.361 |
Posaconazole | 0.031–1 | 0.125 | 0.5 | 0.196 |
Caspofungin | 2–16 | 8 | 16 | 8.903 |
Micafungin | 0.5–32 | 8 | 16 | 8.968 |
Terbinafine | 0.002–1 | 0.125 | 0.25 | 0.143 |
Environmental (n = 15) | ||||
Fluconazole | 16–256 | 64 | 256 | 82.133 |
Flucytosine | 2–64 | 16 | 64 | 24.8 |
Amphotericin B | 2–4 | 4 | 4 | 3.2 |
Itraconazole | 1–4 | 2 | 4 | 2 |
Voriconazole | 0.25–4 | 1 | 2 | 1.033 |
Posaconazole | 0.031–1 | 0.25 | 0.5 | 0.308 |
Caspofungin | 2–16 | 8 | 16 | 9.733 |
Micafungin | 1–32 | 4 | 16 | 7.933 |
Terbinafine | 0.063–0.5 | 0.125 | 0.25 | 0.171 |