TABLE 2.
MIC ranges, geometric mean MICs, FICI ranges, and ratios for 31 clinical strains for which combinations of drugs showed synergy
| Characteristic | Value for indicated antifungal(s)a |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ITC + CAS | ITC | CAS | ITC + MCFG | ITC | MCFG | ITC + TRB | ITC | TRB | AMB + 5FC | AMB | 5FC | |
| MIC range (μg/ml) | 0.031–0.25 | 0.5–16 | 0.031–1 | 0.5–64 | 0.031–0.5 | 0.063–1 | 0.125–4 | 0.5–256 | ||||
| GMb MIC (μg/ml) | 0.088 | 5.435 | 0.347 | 3.161 | 0.152 | 0.371 | 1.21 | 47.951 | ||||
| FICI range | 0.125–0.5 | <0.141–1.25c | 0.245–2 | 0.094–2 | ||||||||
| Ratio (%)d | 100 | 12.9 | 25.8 | 45.2 | ||||||||
a
ITC, itraconazole; CAS, caspofungin; MCFG, micafungin TRB, terbinafine; AMB, amphotericin B; 5FC, flucytosine.
b
GM, geometric mean.
c
The MIC of MCFG used alone was >256 μg/ml for 100% inhibition.
d
The higher the ratio, the more potent the combination.