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Roles of the L1, L3, and L5 loops in recognition of different substrates from NDM-1 structures or docking output of β-lactams with the lowest binding energy in NDM-1. (A) Ampicillin (3Q6X); (B) meropenem (4EYL [yellow]) and imipenem (magenta); (C) ertapenem; (D) cephalothin; (E) ceftriaxone; (F) cefepime.
