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KAF156 is fully protective in a causal prophylactic mouse model of malaria. Mice (n = 5) were infected with P. berghei sporozoites intravenously on day 0 and administered a single dose of compound 2 h before parasite inoculation. Mice were monitored over 30 days for parasitemia. Vehicle used for compound administration was a suspension formulation of 0.5% (wt/vol) methylcellulose and 1% (wt/vol) Solutol HS15. The data represent the numbers of live mice at the indicated day postinfection.
