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Induction of the Dap operon, the Dlt operon, and proteases/chaperones. Heat maps of gene induction (log2 transformed) of the Dlt operon (A), the Dap operon (B), and select proteases and chaperones (C) are shown. Brilacidin and LL16 caused a strong induction of the Dap operon as well as a modest upregulation of the Dlt operon, while daptomycin and higher concentrations of brilacidin treatment caused upregulation of proteases and chaperones.
