TABLE 5.

Gene loci showing modified expression (≥2-fold change) in each of the strains tested under cefoxitin or ceftazidime incubation compared to the same strain under basal conditions as determined using Affymetrix GeneChips

Locus tag	Gene	Product	Fold change/condition under antibiotic conditionsa:
			PAO1 FOX	creBC FOX	PAO1 CAZ	creBC CAZ
PA0465	creD	Inner membrane protein CreD	3.62	−3.2	1.14	1.11
PA0466			2.3	−2.02	1.14	−1.03
PA0509	nirN	Probable c-type cytochrome	2.1	−1.3	−1.16	−1.74
PA0510		Hypothetical protein	2.18	−1.39	−1.44	−2.18
PA0511	nirJ		2.17	−1.2	−1.34	−2.24
PA0512		Conserved hypothetical protein	2.43	−1.22	−1.19	−2.08
PA0513		Probable transcriptional regulator	2.42	−1.12	−1.59	−2.91
PA0514	nirL		2.25	−1.13	−1.28	−2.38
PA0515		Probable transcriptional regulator	2.46	−1.01	−1.17	−2.77
PA0516	nirF		2.74	1.07	−1.33	−2.66
PA0517	nirC		3.56	−1.01	−1.22	−3.66
PA0518	nirM		3.8	−1.05	−1.28	−4.57
PA0519	nirS		3.86	−1.02	−1.21	−4.94
PA0523	norC		1.85		−1.18	−3.45
PA0524	norB		2.43	−1.25	−1.08	−3.91
PA0525		Probable denitrification protein NorD	1.62	−1.29	−1.15	−2.07
PA0918		Cytochrome b561	2.41	−1	−1.14	−1.78
PA1557	ccoN2	Cytochrome c oxidase, cbb3-type, CcoN subunit	1.76	2.25	2.08	2.54
PA1582	sdhD	Succinate dehydrogenase (D subunit)	1.38	1.54	2.02	1.63
PA1588	sucC	Succinyl-CoA synthetase beta chainb	1.55	1.36	2.16	1.46
PA2742	rpmI	50S ribosomal protein L35	1.48	1.61	2.03	1.74
PA3205		Hypothetical protein	1.25	1.55	−2.49	−1.13
PA3392	nosZ	Nitrous oxide reductase precursor	3.79	−1.68	−1.53	−4.1
PA3393	nosD	NosD protein	2.11	−1.39	−1.28	−1.87
PA3394	nosF	NosF protein	2.2	−1.27	−1.24	−1.80
PA3395	nosY	NosY protein	2.21	−1.28	−1.01	−1.26
PA3872	narI	Respiratory nitrate reductase gamma chain	−1.00	−1.49	−1.24	−2.61
PA3873	narJ	Respiratory nitrate reductase delta chain	1.26	−1.34	−1.14	−2.7
PA3874	narH	Respiratory nitrate reductase beta chain	1.15	−1.43	−1.1	−3.37
PA3875	narG	Respiratory nitrate reductase alpha chain	1.19	−1.31	−1.13	−4.73
PA3876	narK2	Nitrite extrusion protein 2	1.09	−1.62	−1.17	−5.08
PA3877	narK1	Nitrite extrusion protein 1	1.18	−1.53	−1.11	−5.34
PA3915	moaB1	Molybdopterin biosynthetic protein B1	−1.03	−1.20	−1.15	−3.67
PA4110	ampC	β-Lactamase precursor	5.16	4.17	1.10	−1.09
PA4238	rpoA	DNA-directed RNA polymerase alpha chain	1.55	1.48	2.01	1.72
PA4242	rpmJ	50S ribosomal protein L36	1.41	1.23	2.03	1.41
PA4246	rpsE	30S ribosomal protein S5	1.46	1.72	2.11	1.91
PA4247	rplR	50S ribosomal protein L18	1.41	1.28	2.03	1.58
PA4254	rpsQ	30S ribosomal protein S17	1.68	1.43	2.41	1.88
PA4257	rpsC	30S ribosomal protein S3	1.78	1.51	2.27	1.92
PA4258	rplV	50S ribosomal protein L22	1.58	1.27	2.01	1.6
PA4260	rplB	50S ribosomal protein L2	1.49	1.24	2.06	1.44
PA4262	rplD	50S ribosomal protein L4	1.56	1.62	2.21	1.71
PA4266	fusA1	Elongation factor G	1.56	1.59	2.1	1.85
PA4268	rpsL	30S ribosomal protein S12	1.96	1.61	2.47	1.63
PA4272	rplJ	50S ribosomal protein L10	1.37	1.36	2.08	1.98
PA4944	hfG		1.88	2.15	1.79	1.97
PA5212		Hypothetical protein	2.01	1.55	−1.00	−1.09

^aBold type indicates increased gene expression (≥2-fold), and italics indicate decreased gene expression (≥2-fold).

^bCoA, coenzyme A.