TABLE 1.
Bacillary burden in the lungs of acutely infected mice during treatment and relapse rates
| Groupa | Log10 CFU count (mean ±SD) atb: |
Relapse rate (no. positive culture/total no. of mice [%]), assessed 3 mo after completion of treatment for: |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| D13 | D0 | M1 | M2 | M3 | M4 | M5 | M6 | M4 | M5 | M6 | |
| Untreated | 4.37 ± 0.07 | 8.28 ± 0.14 | |||||||||
| RIF-INH-PZA | 5.72 ± 0.16 | 3.73 ± 0.15 | 1.82 ± 0.26 | 0.37 ± 0.23 | 0 ± 0 | 0 ± 0 | 9/10 (90) | 2/10 (20) | 0/10 (0) | ||
| RIF-INH-PZA-TRZ | 5.28 ± 0.19 | 3.41 ± 0.3 | 1.31 ± 0.12 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 6/10 (60) | 0/10 (0) | 0/10 (0) | ||
| Total no. of mice | 6 | 5 | 20c | 10 | 10 | 10 | 10 | 10 | 20 | 20 | 20 |
a
Drug doses: 10 mg/kg isoniazid (INH), 10 mg/kg rifampin (RIF), 150 mg/kg pyrazinamide (PZA), and 25 mg/kg thioridazine (TRZ). For the two treated groups, PZA was given for the first 2 months.
b
D, day; M, month.
c
All 10 untreated mice died within 3 weeks.