TABLE 2.
Treatment outcomes with cefazolin and oxacillin for complicated MSSA bacteremia
| Outcome or parameter | Valuea for patients treated with: |
P value | ||
|---|---|---|---|---|
| Overall (n = 93) | Oxacillin (n = 34) | Cefazolin (n = 59) | ||
| Clinical cure at end of therapy | 86 (92) | 32 (88) | 56 (95) | 0.25 |
| Duration of bacteremia (days)b | 4 (2–6) | 4 (3–7) | 4 (2–5) | 0.20 |
| Time to defervescence (days)b | 2 (1–3) | 2 (1–3) | 2 (1–4) | 0.33 |
| Median no. of blood cultures drawnb | 4 (4–8) | 5 (4–9) | 4 (3–8) | 0.21 |
| Median no. of blood cultures positiveb | 4 (3–7) | 4 (3–10) | 4 (2–6) | 0.28 |
| Overall treatment failure | 30 (32) | 16 (47) | 14 (24) | 0.04 |
| Persistent bacteremia | 13/30 (43) | 7/16 (44) | 6/14 (43) | 0.55 |
| Progression of infection on therapy | 9/30 (30) | 5/16 (31) | 4/14 (29) | 0.16 |
| Relapse of infection | 7/30 (23) | 3/16 (19) | 4/14 (29) | 1.0 |
| Death | 1/30 (3) | 1/16 (6) | 0/14 (0) | 0.37 |
| Antibiotic discontinuation due to failure | 1 (1) | 0 (0) | 1 (2) | 0.30 |
| Infection-related 90-day readmission | 13 (14) | 8 (24) | 5 (9) | 0.06 |
| Recurrence of bacteremia | 3 (3) | 2 (6) | 1 (2) | 0.55 |
| 30-day mortality | 1 (1) | 1 (3) | 0 (0) | 0.37 |
| 90-day mortality | 1 (1) | 1 (3) | 0 (0) | 0.37 |
a
Values are numbers (with percentages in parentheses) unless indicated otherwise.
b
Values are medians (with interquartile ranges in parentheses).