TABLE 5.
Description of overall failures in patients receiving cefazolin or oxacillin for complicated MSSA bacteremia
| Patient no. | Antibiotica | Primary reason for failure | Primary sourceb | Treatment duration (days) | Duration of bacteremia (days) | Metastasis? | Received surgical intervention? | Time to surgery (days) | Multiple surgeries needed? | Hardware removal? |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CFZ 2 g post-HD | Persistence | Septic knee and elbow | 26 | 8 | Y | Y | 14 | N | |
| 2 | CFZ 6 g (CI) | Persistence | Right and left-sided IE | 36 | 10 | Y | N | |||
| 3 | CFZ 6 g (CI) | Persistence | Septic shoulder | 46 | 7 | N | Y | 4 | Y | |
| 4 | CFZ 6 g (II) | Persistence | Septic phlebitis | 42 | 8 | Y | N | |||
| 5 | CFZ 6 g (CI) | Persistence | Renal abscess | 42 | 8 | N | Y | 2 | N | |
| 6 | CFZ 6 g (CI) | Persistence | Paraspinal abscess | 69 | 10 | Y | Y | 13 | Y | N |
| 7 | CFZ 6 g (II) | Progression | Paramediastinal abscess with OM | 28 | 1 | N | N | |||
| 8 | CFZ 6 g (II) | Progression | Psoas abscess | 26 | 3 | Y | N | |||
| 9 | CFZ 2 g post-HD | Progression | AV graft infection | 42 | 3 | N | Y | 4 | N | N |
| 10 | CFZ 8 g (CI) | Progression | Epidural and psoas abscess with OM | 96 | 17 | N | Y | 9 | Y | N |
| 11 | CFZ 4 g (II) | Relapse | Lumbar abscess | 12 | 2 | N | Y | 1 | Y | |
| 12 | CFZ 6 g (CI) | Relapse | Possible endocarditis | 35 | 1 | Y | N | |||
| 13 | CFZ 6 g (II) | Relapse | Septic knee | 39 | 1 | N | Y | 1 | N | |
| 14 | CFZ 6 g (CI) | Relapse | Left-sided endocarditis | 44 | 3 | Y | N | |||
| 15 | OX 12 g (CI) | Death | Right-sided endocarditis with ICD infection | 30 | 9 | N | N | N | ||
| 16 | OX 12 g (CI) | Persistence | Septic knee, ankle, and subclavian joints | 42 | 9 | Y | Y | 4 | Y | |
| 17 | OX 12 g (CI) | Persistence | Septic knee and shoulder | 42 | 8 | N | Y | 10 | N | |
| 18 | OX 12 g (CI) | Persistence | Renal and prostate abscess | 28 | 8 | Y | Y | 2 | N | |
| 19 | OX 12 g (CI) | Persistence | Septic elbow and knees | 30 | 9 | Y | Y | 7 | N | |
| 20 | OX 12 g (CI) | Persistence | Humerus muscle abscess | 46 | 7 | N | Y | 1 | Y | |
| 21 | OX 12 g (CI) | Persistence | Vertebral OM | 17 | 9 | Y | N | |||
| 22 | OX 12 g (CI) | Persistence | Hip OM | 15 | 7 | N | Y | 8 | N | |
| 23 | OX 10 g (CI) | Progression | Pleural abscess | 14 | 4 | N | N | |||
| 24 | OX 12 g (CI) | Progression | Epidural abscess | 42 | 8 | N | Y | 6 | N | |
| 25 | OX 12 g (CI) | Progression | Septic subclavian joint with vertebral OM | 45 | 4 | Y | Y | 4 | N | |
| 26 | OX 12 g (CI) | Progression | Septic ankle and epidural abscess with vertebral OM | 55 | 8 | Y | Y | 5 | Y | |
| 27 | OX 12 g (CI) | Progression | Craniotomy bone flap infection | 37 | 4 | N | N | |||
| 28 | OX 12 g (CI) | Relapse | Vertebral OM | 42 | 2 | N | N | |||
| 29 | OX 12 g (CI) | Relapse | Unknown | 14 | 3 | Y | N | |||
| 30 | OX 12 g (II) | Relapse | Foot abscess with OM | 58 | 5 | N | Y | 3 | N |
a
The total daily dose is reported for patients not on hemodialysis. CFZ, cefazolin; OX, oxacillin; CI, continuous infusion; II, intermittent infusion; HD, hemodialysis.
b
IE, infective endocarditis; OM, osteomyelitis; AV, arteriovenous; ICD, intracardiac device.