TABLE 4.
Summary statistics for sputum amikacin concentrations (μg/g), stratified by dose and study day
| Day and time | Median (min, max) sputum amikacin concn (μg/g) by dose (mg)a: |
|||
|---|---|---|---|---|
| 70 | 140 | 280 | 560 | |
| Day 1 | ||||
| 1 h postdose | 1,266 (110, 2,292) | 1,626 (1,032, 2,550) | 915 (15.2, 1,867) | 2,286 (11.6, 11,220) |
| Day 14 | ||||
| Predose | 29.8 (4.47, 900) | 18.1 (11.4, 32.9) | 19.3 (1.8, 106) | 35.9 (2.17, 906) |
| 1 h postdose | 599 (85.8, 3,420) | 1,086 (930, 3,228) | 822 (58.4, 4,278) | 2,187 (5.79, 13,014) |
| Day 28 | ||||
| Predose | 12.8 (4.57, 241) | 20.2 (9.36, 39.4) | 14.9 (1.27, 302) | 41.1 (3.29, 452.5) |
| 1 h postdose | 449 (207, 1,758) | 1,050 (654, 3,828) | 1,233 (68.4, 11,160) | 1,758 (8.28, 15,109) |
a
min, minimum; max, maximum.